"Sinecode" for children is one of the non-narcotic antitussive drugs. A positive effect of the drug is achieved due to its ability to inhibit the work of the cough center, located in the medulla oblongata.
Consider in more detail the information about the synecod syrup for children and instructions for use.
pharmachologic effect
The active component of Sinecode (butamirate) is an antitussive with a central type of action. Neither pharmacologically nor chemically, it can be attributed to opium alkaloids.
Butamylate citrate has a bronchodilating effect. In addition, it reduces airway resistance and promotes better oxygen saturation of the blood.
Let us explain the principle of action in simpler words: the drug blocks the receptors in the brain that are responsible for the cough reflex, as a result, the signal does not reach the bronchi, and the attack stops.
By increasing the amount of oxygen in the lungs, tissues are saturated with a large amount of nutrients. As a result, the baby's condition improves and he is recovering faster.
Despite such a powerful effect on the body, the substance is not addictive or addictive, and also does not accumulate in the body. It can be used for treatment over a long period of time.
The substance is well tolerated by both adults and children.
Pharmacokinetics
When taking Sinecode, its main active component (butamirate) is quickly and completely absorbed into the bloodstream. At the same time, metabolites are produced in the blood plasma: diethylaminoectoxyethanol and 2-phenylbutyric acid. Studies have shown that the content of these substances directly depends on the amount of the drug taken.
After internal use of butamirate, the substance can be found in the blood after 5-10 minutes. Regardless of the amount of the drug taken, the maximum concentration of this component in the blood occurs after 60 minutes.
After applying Sinecode, its main active substance can be found in urine for another two days.
The level of 2-phenylbutyric acid reaches its average value in the blood within 90 minutes, and diethylaminoectoxyethanol - 40-41 minutes.
Metabolites of butamirate have an antitussive effect and the property of binding to blood plasma proteins. Their elimination from the body occurs to a greater extent through the kidneys. The exception is only those species that have an acid reaction. They will bind to glucuronic acid. This will happen after conjugation in the liver.
What the drug consists of and in what form it goes on sale
The main active ingredient of the drug is butamirate. It is this component that affects the desired part of the brain and reduces the manifestation of the cough reflex. In addition to it, the medicine also contains auxiliary components: glycerol, benzoic acid, sorbitol solution, sodium hydroxide, vanillin and others (for a complete list, see the instructions for Sinecode for children).
Additional components are needed in order to give the drug the desired consistency, pleasant smell and taste.
The drug is available and goes on sale in the form of:
- Drops for internal use. Available in pharmacies in dark glass bottles with a volume of 20 ml. The drops have a vanilla odor. For greater ease of use of the drug, the bottle is equipped with a dropper dispenser.
- Syrup. Available in pharmacies in dark glass bottles of 100 and 200 ml. Additionally, a measuring cap is included. The lid of the drug is equipped with a special protection system that prevents the child from opening the bottle accidentally. The syrup has a pleasant vanilla odor.
- Dragee. Available in packs of 10 pieces. One tablet contains 20 mg of the active ingredient.
In the article below, we will consider what differences exist between these two types of the same medication.
Indications for use
The use of "Sinecode" for children is shown:
- with ARI, SARS, flu, whooping cough;
- in the presence of discomfort during respiratory diseases (pharyngitis, tracheitis, pleurisy, bronchial asthma, laryngitis, etc.).
- to suppress dry cough during surgery;
- to suppress the cough reflex in the pre-, postoperative period.
Rules of use and dosage
In the composition of the drops and syrup "Sinecode" there are no significant differences. The main one consists in the amount of active substance in 1 ml of the drug: 5 mg in drops and 1.5 mg in syrup.
That is why the method of application of the drug will differ depending on its type. Let's pay attention to the main nuances.
Important! The instructions for the drug indicate only an approximate treatment regimen! The exact dosage will be determined by a specialist, based on the health status of the baby and some other indicators.
Instructions for use of drops "Sinecode" for children:
- children older than 3 years and adolescents - no more than 4 times a day, 25 drops;
- at the age of 1 to 3 years - no more than 4 times a day, 15 drops;
- at the age of 2 months to 1 year - no more than 4 times a day, 10 drops.
Unlike drops, "Sinecode" in the form of a syrup is intended for older children. It is prohibited for use by babies who are under 3 years old.
Instructions for syrup "Sinecode" for children:
- children from 12 years of age and older - no more than 3 times a day, 15 ml each;
- at the age of 6 to 12 years - no more than 3 times a day for 10 ml;
- at the age of 3 to 6 years - no more than 3 times a day, 5 ml each.
Dragee "Sinecode" is assigned to children over 6 years of age. Permissible dosages in this case are as follows:
- at the age of 12 to 18 years - 3 times a day for 1 tablet;
- at the age of 6 to 12 years - 2 times a day for 1 dragee.
According to the instructions for use, "Sinecode" for children should be taken before meals. It is very important to pre-shake the bottle with the drug so that its contents mix well. After the child has been given the right amount of medicine, it is necessary to give him drink it with water or breast milk.
It is allowed to use only a dry and clean measuring cup, so after each use it must be thoroughly rinsed.
The duration of treatment with Sinecode is determined by the doctor individually. Usually it is about 5-7 days. If there is no improvement during this time, a decision is made to adjust the therapy or a replacement drug is selected.
Overdose
Non-observance of the doses of the drug prescribed by the doctor can lead to the appearance of symptoms such as:
- lowering blood pressure;
- nausea;
- diarrhea;
- vomiting
- drowsiness;
- dizziness.
Therefore, it is important to adhere to the standards specified in the instructions to the "Sinecode" for children.
If it still happened that there were signs of an overdose, the patient will benefit from taking activated charcoal or other enterosorbents, osmotic laxatives, and gastric lavage. In this case, special attention is paid to monitoring and, if necessary, maintaining the work of the heart and respiratory system.
At the moment, there is no special antidote that will eliminate all signs of an overdose of Sinecode.
Contraindications
There are several contraindications to the use of the drug:
- In the presence of hypersensitivity to the components of the drug.
- In the presence of pulmonary bleeding.
- According to the instructions, Sinecode drops for children are prohibited until the baby reaches 2 months of age. Syrup can be taken only from 3 years. The minimum age for using dragees is 6 years.
With extreme caution, this medicine is prescribed for children with epilepsy, obesity, kidney and brain diseases.
Side effects
Side effects from the use of the drug are very rare. Nevertheless, the instruction to Sinecode for children warns of possible negative reactions, such as:
- nausea;
- diarrhea;
- vomiting
- allergic manifestations (rash, urticaria, itching, exanthema);
- dizziness.
If they occur, you should cancel the use of the drug and consult a doctor to find a remedy with a similar type of action.
Analogs
There are many medicines, the composition and principle of action of which are similar to the "Sinecode" for children. Most often, the drug is replaced with such non-narcotic drugs as:
- "Bronchoton";
- “Codelac Neo”;
- "Bronchicine";
- Omnitus
- "Bronchitusen Vramed" (syrup);
- Stoptusin;
- "Broncholitin sage" (syrup);
- "Pakseladin";
- Libexin.
The advisability of replacing the "Sinecode" with an analogue must first consult with your doctor!
Storage conditions and shelf life
Sinecode for children should be stored in a cool place (temperature should not exceed 30 degrees) out of the reach of children.
The shelf life of the product in unopened packaging is 5 years. After opening the bottle, you must use the drug for 6 months. Treatment with an expired product is strictly prohibited!
Additional Information
"Sinecode" for children suppresses the cough reflex, therefore, it is not recommended to take it in combination with expectorants (for example, "Lazolvan"). Otherwise, there is a risk of sputum accumulation, which can lead to the development of bronchospasm or respiratory tract infection. It is also forbidden to use "Sinecode" along with drugs that stop coughing attacks of any etiology.
The tool is not used in combination with psychotropic medicines (antidepressants, antipsychotics, tranquilizers, etc.).
Drops and Sinecode syrup for children can be prescribed for patients with diabetes mellitus. As sweeteners, it contains saccharin and sorbitol, which are harmless for this group of patients.
It is important to remember that Sinecode does not eliminate a dry cough, but only temporarily facilitates its manifestation. Therefore, for the full treatment, other drugs are simultaneously used. These can be antibiotics and antiviral agents, as well as physiotherapeutic procedures.
"Sinecode" refers to a group of medicines that can be bought without a doctor’s prescription. But this does not give the right to self-medicate!
Reviews
Doctors leave positive reviews about Sinecode for children. The main advantages of the drug they call:
- the possibility of application to infants;
- complete safety for health;
- rapid achievement of a positive effect;
- normalization of respiratory processes without a direct effect on the respiratory center;
- fast elimination from the body;
- lack of harmful effects on the organs of the gastrointestinal tract;
- the absence of narcotic additives in Sinecode;
- the possibility of using for a long course of treatment.
At the same time, they note that "Sinekod" is a potent drug. Therefore, its independent admission without a doctor’s appointment is strictly prohibited! In addition, the tool blocks coughing attacks, which means that in the presence of sputum, its excretion does not occur. This can lead to the development of pneumonia and other complications mentioned above. To avoid unpleasant consequences, absolutely all experts recommend using the drug only under the close supervision of the attending physician.
What do parents say about Sinecode? Most reviews of the drug are positive. Moms and dads note the rapid onset of a positive effect and its persistence throughout the course of treatment. The medication is well tolerated by the body of even the smallest children and, if properly followed, does not cause side effects.
After analyzing the negative reviews, you can notice a pattern: they are left by those who "prescribed" the use of "Sinecode" on their own and did not adhere to the correct dosages. Although there are several other drawbacks of the drug that parents noted: the rather high cost of Sinecode in the form of drops (about 400 rubles per bottle) and the unpleasant bitter taste of the syrup, which young children do not like.