In the article, we consider the instructions for ascorbic acid from Pharmstandard.
This is the largest Russian pharmaceutical company, producing a wide range of safe, high-quality pharmaceutical products created according to the standards of relevant manufacturing practice. One of them is ascorbic acid.
Composition and form of release
Pharmstandard ascorbic acid is available as a dragee containing 50 mg of the basic substance. The package contains 150 pieces.
Also on sale you can find ascorbic acid from Pharmstandard in a dragee x200 pcs.
In addition, the company produces ascorbic acid with glucose - in the form of tablets containing 100 mg of the main substance and 877 mg of dextrose.
Pharmacological properties
Pharmstandard ascorbic acid promotes the stimulation of redox reactions in the body, normalizes carbohydrate metabolism, regulates blood coagulation, tissue repair, steroid hormones, helps to produce collagen and collagen, and normalizes capillary permeability. The substance does not form on its own in the human body, but enters as part of food. With a full and balanced diet, a person does not lack vitamin C.
In combination with glucose, ascorbic acid has a metabolic effect, is involved in the regulation of oxidative processes, in the production of steroid hormones, reduces vascular permeability, reduces the need for folic and pantothenic acid, vitamins B 1 , A, B 2 , E.
List of indications for use
Pharmstandard ascorbic acid is used for prophylactic and therapeutic purposes in all clinical cases, due to the need for additional vitamin C intake by the body. This drug is prescribed for the prevention and treatment of scurvy, with nose, uterine, pulmonary hemorrhages caused by radiation sickness. In addition, it is successfully used in hemorrhagic diathesis, with various intoxications and infectious pathologies, Addison’s disease, pregnant nephropathy, with an overdose of anticoagulants, sluggish wounds and various fractures, various dystrophies, with high mental stress and excessive physical exertion.
Contraindications
Pharmstandard ascorbic acid is contraindicated for use in such cases:
- hypersensitivity;
- prolonged use in large doses (more than 500 mg);
- nephrolithiasis;
- hyperoxaluria;
- hemochromatosis;
- diabetes;
- glucose-6-phosphate dehydrogenase deficiency;
- thalassemia.
With caution, it is used for sideroblastic anemia and urolithiasis.
Use during pregnancy and lactation
During pregnancy and lactation, this medication is used if the positive effect for the mother outweighs the risk for the baby. The minimum daily requirement for this substance in the II-III trimesters of pregnancy is approximately 60 mg. It should be borne in mind that the fetus can adapt to the increased doses of ascorbic acid that a woman takes during pregnancy, but subsequently a "withdrawal" syndrome may occur in the newborn. During lactation, the daily need for this substance is 80 mg.
How to apply ascorbic acid with glucose from Pharmstandard?
Instructions for use
For prevention, adults are prescribed 0.05-0.1 g per day, during pregnancy, after childbirth and in case of vitamin C deficiency in the milk of women during lactation - 0.3 g per day for a period of 10- 15 days, after which the dose is reduced to prophylactic - 0.1 g per day throughout the entire lactation period.
For preventive purposes, children are prescribed 0.025 g 2-3 times a day. Therapeutic doses for children - 0.05-0.1 g 2-3 times a day.
Adverse reactions
According to the instructions for use, ascorbic acid from Pharmstandard can provoke the development of the following negative phenomena:
- CNS: with rapid intravenous administration - a feeling of tiredness, dizziness, with prolonged use of large doses (more than 1 g) - cephalgia, increased nervous system excitability, sleep disturbance.
- Urinary system: moderate pollakiuria, with prolonged use - nephrolithiasis, hyperoxaluria, damage to the glomerular structure of the kidneys.
- Cardiovascular system: with prolonged use in high doses - a decrease in capillary permeability, inhibition of tissue trophism, increased blood pressure, the occurrence of microangiopathies, hypercoagulation.
- Allergic reactions: rashes, anaphylactic shock.
- Laboratory indicators: hyperprothrombinemia, thrombocytosis, erythropenia, hypokalemia, neutrophilic leukocytosis, glucosuria.
Special recommendations
Due to the stimulating effect of ascorbic acid on the production of corticosteroid hormones, doctors are advised to monitor blood pressure and adrenal function. High doses enhance the excretion of oxalates, contribute to the formation of kidney stones. In newborns whose mothers took high doses of the drug, "scorching" scurvy may be noted. With prolonged use of large dosages, the functioning of the insular apparatus of the pancreas can be inhibited, and therefore it must be controlled during therapy.
Patients with an increased concentration of iron in the body need to use ascorbic acid in small doses.
Vitami C, as a reducing agent, contributes to the distortion of the results of various laboratory tests (the content of bilirubin, sugars, liver transaminases and lactate dehydrogenase activity in urine and blood).
Drug interaction
Ascorbic acid 200 tablets of Pharmstandard is pharmaceutically incompatible with bleomycin, aminophylline, cefazolin, chlordiazepoxide, cefapirin, benzylpenicillin, estrogens, doxapram, dextrans, erythromycin, nafcillin, methicillin, warfarin.
It increases the content of tetracyclines and benzylpenicillin in the blood in the body, at a dosage of 1 g per day, increases the bioavailability of ethinyl estradiol (for example, present in oral contraceptives), reduces the activity of indirect anticoagulants and heparin.
When combined with acetylsalicylic acid, the excretion of ascorbic acid with urine increases and the level of acetylsalicylic acid excretion decreases.
The substance increases the likelihood of crystalluria during treatment with shortened sulfanilamides and salicylates, slows down the excretion of acids, enhances the excretion of drugs with an alkaline reaction (including alkaloids), reduces the content of oral contraceptives in the blood, increases the overall clearance of ethanol, which provokes decrease in the content of ascorbic acid.
Quinoline drugs, salicylates, calcium preparations, glucocorticosteroids with prolonged use reduce the body's reserves of ascorbic acid.
With concomitant use, reduces the chronotropic effects of isoprenaline.
With long-term use or the use of high doses of ascorbic acid can inhibit the interaction of ethanol and disulfiram, increase kidney excretion of mexiletine. Primidone and barbiturates increase excretion of the main substance in the urine.
Reduces the therapeutic properties of antipsychotics (antipsychotic drugs) - phenothiazine derivatives, as well as reabsorption of tricyclic antidepressants and amphetamine in the tubules of the kidneys.
Reviews
Probably, every person at least once in his life took vitamin C preparations. This substance is very useful, according to most people, it helps to increase immunity and fight infections. Pharmstandard ascorbic acid tablets, including those with glucose content, are very popular. There are a lot of positive reviews about this drug. Patients note that this is an inexpensive pharmaceutical product that is absolutely safe for children and adults, especially if you do not exceed the allowable dose. The drug tastes good, practically does not cause side effects and complications with prolonged use. In the form of dragees, this acid is very popular with children, and many parents give them this remedy for the prevention of acute respiratory viral infections during an increase in the incidence of colds, most often in autumn and spring.