Deficiency in the body of vitamin B 12 leads to a number of different diseases. This is a very important component for the functioning of all systems, which reduces susceptibility to infection and increases stamina, and at the same time mental and physical activity.
About the drug
You should not be scared at all if the doctor prescribed a prescription for cyanocobalamin. This term means vitamin, popularly known as B 12 . Like other substances from this group, it takes an important part in the functioning of vital processes in the human body. As for its lack - it can negatively affect the general state of health.
The name of this drug comes from the only active component in its composition. This pharmaceutical agent can have a hematopoietic effect on the body, due to which cellular metabolism is stimulated. It is prescribed for neurological and dermatological diseases, as part of the complex treatment of blood and liver diseases, and it can also be recommended in order to prevent the development of certain pathological conditions. Vitamin B 12 in combination with other minerals contributes to the overall strengthening of immunity, and at the same time improves the appearance of a person as a whole, as it has a very positive effect on the condition of hair and skin.
Cyanocobalamin (vitamin B12) favors better tissue regeneration, it has a positive effect on the circulatory and nervous system. It can also have a beneficial effect on the functioning of the liver by regulating blood coagulation. In this article, we will talk in detail about this vitamin, learn about its contraindications and indications, positive as well as negative effects, consider modern analogues in the pharmaceutical market and patient reviews.
Here is a recipe for Latin cyanocobalamin. Rp: Sol. Cyancobalamini 0.05%, 1 ml, which means the use of 1 milliliter (intramuscularly).
The role of B12 in the human body
Cyanocobalamin (i.e., vitamin B 12 ) was first discovered back in 1948. Scientists have isolated a new component from a raw liver, and it has been prescribed for the treatment of malignant forms of anemia. Over the past seventy years, the substance has been well studied by scientists and physicians, as a result of which they were able to determine its effect on the human body:
- Stress hormone blocking.
- Improving blood coagulation.
- The process of synthesis of amino acids.
- Decreased blood cholesterol.
- The implementation of detoxification of the body on the background of alcoholism.
- Significant improvement in liver function.
This vitamin helps athletes to withstand a large load, among other things, it accelerates weight loss, preventing the development of heart and vascular diseases. The drug plays a large role in the functioning of the nervous system. Vitamin supplemented with the main therapy of cerebral palsy in children, the fight against Down syndrome, as well as the treatment of intercostal neuralgia and so on.
Release form
Cyanocobalamin is produced today in a single form - in a solution for intravenous, subcutaneous, intramuscular, as well as intralumbal use. That is, people are given injections of vitamin B 12 . There are different dosages, depending on this, the color of the liquid can change, starting from pink, ending with a rich red tint.
They produce vitamin in ampoules, which are packed in contour cells, and can also be delivered in cardboard boxes that fit in a box. In each ampoule, 1 milliliter of a solution that contains 0.2 or 0.5 milligrams of cyanocobalamin. Auxiliary components are sodium chloride and water for injection.
Let’s see how vitamin B12 is useful in injections.
Pharmacodynamics of the drug
This drug belongs to the pharmacological category of vitamins. Cyanocobalamin usually penetrates the liver, where it is subsequently metabolized. Then it is converted into the following two substances: methylcobalamin, as well as deoxyadenosylcobalamin. The first component is an active participant in the processes of conversion of homocysteine to adenosylmethionine and methionine. The second element is one of the most important in the process of carrying out the metabolism of lipids and carbohydrates.
Thus, a deficiency of vitamin B12 in the human body can lead to a violation of the proliferation of rapidly dividing cellular elements of the epithelium and hematopoietic tissue, as well as to a malfunction during the formation of the myelin neural membrane. The most common and widely produced chemical compound with vitamin B 12 activity is cyanocobalamin, although this substance is almost one hundred percent artificial. It is worth noting that cyanocobalamin is not found in living organisms, but can be converted to any active compound B 12 as part of the ingestion. In other words, cyanocobalamin is the vitamer (or form) of the original vitamin.
Regarding pharmacokinetics, this artificial substance, penetrating into the blood, can bind to transcobalamin, which transport B 12 into the tissue. Subsequently, it accumulates in the liver and is then independently consumed by the body through the withdrawal of bile into the intestines, and from there it can again be absorbed into the blood. The half-life of this element is five hundred days.
Indications for use of this vitamin preparation
Vitamin B 12 injections are used as part of adjunctive therapy. They increase the effect of drugs, the medicine helps the human body to overcome many diseases. In rare situations, he is prescribed as the only means to prevent anemia. The main indications for the use of vitamins B12 in injections are chronic migraine along with Down syndrome, cerebral palsy, neuralgia, radiation sickness, alcohol poisoning, dystrophy, anemia, radiculitis, pancreatic disease, as well as liver. Among other things, it is advisable to use it for gastritis, photodermatosis and sclerosis.
Injections of vitamins B6 and B12 are prescribed to people with vitamin deficiency, and in addition, against the background of frequent respiratory diseases. The lack of this element in the body leads to a significant deterioration in the condition of nails, hair and teeth. For these reasons, the use of this drug in ampoules is made not only for therapeutic purposes, but also as part of cosmetic prevention.
Instructions for use of cyanocobalamin injections
When a person is prescribed B 12 , the instructions will help calculate the correct dosage. The treatment regimen usually looks as follows:
- For the prevention of anemia, exactly, like vitamin deficiency, 200 to 500 micrograms per day are used. The course of treatment in this case is from seven to fifteen days.
- To combat diseases of the nervous system, 200 micrograms are injected daily for the first three days. Next, 300 micrograms for four days.
- In the event that cyanocobalamin is used for complex treatment, the dosage will be from 200 to 500 micrograms per day.
Take this vitamin only in the amount recommended by your doctor. It is undesirable to use it independently, since it is rather difficult to establish an individual treatment regimen. Instructions for use for injections of cyanocobalamin should be strictly observed.
How to do injections of this vitamin?
The introduction of the vitamin in question can be carried out in various ways, for example, subcutaneously, intramuscularly, intravenously, and also directly into the spinal cord. The instructions indicate that cyanocobalamin can not be used simultaneously with drugs that increase blood coagulation, and in addition, with vitamin B 1 . In the event that there is an allergy to B 1 , B 12 is able to further strengthen it. It is possible to administer this drug intravenously, as well as intramuscularly, independently. But if it is necessary to inject vitamin B12 directly into the spinal cord, an experienced doctor should do the injection.
Storage conditions
B12 in ampoules is stored exclusively in a dry as well as in a dark place, in the presence of an air temperature of not more than twenty-five degrees. Some complex medicines may require refrigeration. This moment is best specified in the instructions. The main thing to remember is that you can not use this substance after the expiration date indicated on the package.
Drug dosage
What is the dosage of vitamin B12 for injections? The amount of this substance is determined individually, the dose depends on the age of the patient. The maximum daily norm, as a rule, is 400 micrograms for children, and 1000 for adults. Dosage is increased gradually, while it is advisable to start with small portions of the drug. This is required to exclude an allergic reaction.
Contraindications and side effects of these vitamins in injections
Why do we need vitamin B12 in injections, we explained. Subject to the instructions for use and the recommendations of the doctor, the negative effects of the drug in question as such are completely absent. In exceptional cases, unpleasant symptoms in the form of nervous excitement, tachycardia, headache, discomfort in the heart, increased blood pressure, and dizziness are likely to occur.
In the event that a person has an individual intolerance to injections of vitamin B12, an allergic reaction may occur in the form of skin itching, the appearance of a rash, and also a runny nose. When side effects are observed, the administration of the drug immediately stops, and the treatment method is reviewed with the doctor. Immediately before the start of the injection course, you should definitely study the list of contraindications available, which include angina pectoris along with erythrocytosis, thrombosis, varicose veins, pregnancy and lactation, hemorrhoids and oncological diseases.
Another contraindication, according to the instructions, is considered individual intolerance to the substance of cyanocobalamin. It is important to follow the recommendations from the annotation to prevent overdose of vitamin B 12 . Otherwise, in this case, the following manifestations can be observed: the occurrence of heart failure, arrhythmia, pulmonary edema, rash and anaphylactic shock.
It is worth noting that cyanocobalamin makes an invaluable contribution to the work of the human body. With its deficiency, various diseases develop, and in addition, the appearance and general well-being worsen. But you need to take the vitamin only after consulting a doctor and determining the individual dosage. Next, let's talk about the combination of B 12 with various drugs. We will specify the price of cyanocobalamin below.
Interaction
It should be mentioned that cyanocobalamin conflicts with many other representatives of group B, whether thiamine, riboflavin or pyridoxine. Especially dangerous is its combined use with the first, since B 12 can enhance the allergic reaction to thiamine. It is also pharmacologically incompatible with ascorbic acid.
The absorption of cyanocobalamin is significantly reduced in case of co-administration with substances in the form of aminoglycosides, tetracyclines, polymyxin salicylates, colchicine antiepileptic drugs, and so on. Cyanocobalamin is not combined with drugs from a series of coagulants, as well as with oral contraceptives. With the combined use of the drug with most antibiotics and antimetabolites, the actual content of cyanocobalamin in the blood cannot be determined within the framework of microbiological studies.
Vitamin B12 analogs
For some reason, people may need a replacement for this drug. It is worth noting that there are only a few analogues with cyanocobalamin - these are pharmaceuticals such as Triovit along with Neuromine, Medivitan and Neurocobal. Replacement of cyanocobalamin with the above drugs can only be prescribed by the attending doctor. In addition, a mandatory study of the instructions for each of the analogues is required in order to exclude certain contraindications.
The price of cyanocobalamin
The cost of the drug in question is affordable. For one package of ampoules you need to pay only twenty-eight rubles. A Latin cyanocobalamin prescription will need to be provided to a pharmacist.
Next, we learn what they say about the injections in 12 patients who happened to take the appropriate course.
Reviews
Patients write that, like therapy with any other means, the main thing when using cyanocobalamin is the correct dosage in combination with an adequate treatment regimen and duration of the course. If you follow the basic rules, then absolutely no problems will arise with health. You can verify this if you study the reviews about the drug.
Despite the fact that this vitamin has a low price, according to consumers, it works perfectly. It is reported that, whatever the indications for use, cyanocobalamin will fulfill its task one hundred percent, filling the lack of vitamin B 12 in the body as quickly as possible.
In addition, people who have been treated with this substance report mild tolerance to the drug. Course therapy contributes to a marked improvement in overall well-being. For example, patients in the reviews say that while taking this drug, their stamina increased, drowsiness and apathy disappeared. Among other things, cyanocobalamin strengthens the immune system, positively affecting the hematopoiesis system and improving blood circulation in general.
Those who managed to test this medicine on themselves already probably know: if the doctor prescribed them this drug, then you can expect high results from the selected treatment. In addition, many girls use the contents of ampoules to repair damaged hair. With the addition of a solution of cyanocobalamin, masks are prepared, and also rubbed in its pure form into the roots. In this case, reviews can also be read only positive - curls strengthen, dandruff disappears, shine appears. Thus, if anyone else doubts the effectiveness of the drug in question, do not worry about it. The main thing is that the treatment is carried out as prescribed by the doctor.
Does it hurt to give injections?
People often ask if B12 injections hurt. As you know, injections of B vitamins are always painful. But, as patients who have undergone a course of cyanocobalamin, they can not be afraid, since from the whole group B such injections are just considered less painful. Now we find out in which products this useful substance is located and whether it can be obtained from food, and not from artificial compounds.
Where is vitamin B12 contained?
It is important to understand that this substance is not synthesized by animals or plants, and its assimilation after ingestion with products directly depends on how well this vitamin is stored in the body. It is worth noting that this is better for animals, therefore, almost all sources of vitamin B 12 are of animal origin.
Thus, in order to add B 12 to your diet, first of all, you need to pay attention to calf liver, and in addition to salmon, lamb, beef, shrimp, cod and sardines. If a person is more interested in plants, it is better to choose algae (kelp) along with brewer's yeast, miso sauce and tofu. In the latter case, of course, we must remember that the content of B 12 in them will be several times lower in comparison with products of animal origin.
Is the simultaneous use of several vitamins?
Vitamin B 6 is used for fatigue and stress, and is also often used in the treatment of pathologies of the nervous system, heart and joints.
Let’s figure out whether it is possible to simultaneously inject B6 and B12. The beneficial effect of combining these vitamins is widely known. The fact is that such a combination can mutually enhance the effectiveness of both therapeutic substances. According to the latest information from American scientists, the simultaneous administration of these drugs helps to reduce homocysteine levels in the body, which helps to reduce the risks of cardiac and vascular pathologies.
In order for the intake of these vitamins to bring benefits to the person, and not harm, their pharmacological characteristics must be taken into account. As part of the prevention, it will be enough to take nutritional supplements in capsules, and directly with vitamin deficiencies, injections may be required. These substances can be mixed with folic acid, but simultaneous administration of B 1 with pyridoxine or cyanocobalamin is undesirable. Before using it, in any case, consult your doctor.